Mishra had got off to a horrendous start to his spell as he was taken for a couple of fours by Suryakumar Yadav.
Rohit Sharma meted out the same treatment to the veteran leg-spinner in his second over as he cut a short and wide delivery past the third man.
But Amit Mishra once again proved just why he is the second-highest wicket-taker in the history of the IPL as he tossed the ball up, dragged it wide of off-stump to entice Rohit Sharma into a false lofted stroke over long-on.
Rohit did not get to the pitch of the ball and ended up miscuing it straight to Steve Smith at long-on, paving way for a guttural roar from Amit Mishra.
Rohit’s wicket came at a vital time for Delhi Capitals as the Mumbai Indians skipper was batting like a dream.
Sharma, who registered his highest IPL 2021 score, smashed three fours and as many sixes during his 30-ball 44.
One ball later, Amit Mishra dealt another body blow on the defending champions as he dismissed Hardik Pandya in the exact same manner as Rohit.
Mumbai Indians lost yet another wicket in the form of Krunal Pandya, who bamboozled the all-rounder with a brilliant arm-ball before Mishra chipped in again to knock over Kieron Pollard with a googly, leaving MI reeling at 6/87.